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Structural insights into how 5-hydroxymethylation influences transcription factor binding

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Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3CC48151D, Communication
Lukas Lercher, Michael A. McDonough, Afaf H. El-Sagheer, Armin Thalhammer, Skirmantas Kriaucionis, Tom Brown, Christopher J. Schofield
High resolution crystallographic studies of DNA duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications can regulate transcription by context dependent effects on DNA transcription factor interactions.
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