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Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C-H activation reaction

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Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC45449E, Communication
Nana Zhang, Qingzhen Yu, Ruixue Chen, Jianhui Huang, Yeqing Xia, Kang Zhao
A novel Pd-catalysed C-H activation reaction for the synthesis of biaryl imino/keto carboxylic acids is developed. This reaction underwent aryl amide directed C-H activation ortho-acylation followed by ring closing and ring opening processes to give a range of biaryl imino/keto carboxylic acids.
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