The bulky side chain of antillatoxin is important for potent toxicity: Rational design of photoresponsive cytotoxins based on SAR studies

Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC44066D, Communication

Ken Okura, Shigeru Matsuoka, Masayuki Inoue
Antillatoxin is a cyclic peptide with potent neurotoxic and neuritogenic activities. We designed and synthesized six analogues that have photocleavable protecting groups at the terminus of the side chain. Among...
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