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Backbone-modified molecular beacons for highly sensitive and selective detection of microRNAs based on duplex specific nuclease signal amplification

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Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC43224F, Communication
Xiaoyan Lin, Cheng Zhang, Yishun Huang, Zhi Zhu, Xi Chen, Chaoyong James Yang
Based on backbone-modified molecular beacons and duplex-specific nuclease, we have developed a target recycling amplification method for highly sensitive and selective miRNA detection in complex biological samples.
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