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Versatile Construction of Functionalized Tropane Ring Systems Based on Lactam Activation: Enantioselective Synthesis of (+)-Pervilleine B

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Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC43665A, Communication
Suyu Huang, Zong Chang, Shi-Chuan Tuo, Long-Hui Gao, Ai-E Wang, Huang Pei-Qiang
The halo-assisted intramolecular addition of silyl enol ether with in situ activated lactam yieled (hydroxylated) 1-halo-8-azabicyclo[3,2,1]octane and 1-halo-9-azabicyclo[3,3,1]nonane ring systems, which provided an easy enantioselective access to 6b-silyloxyoxytropane-3-one, 3a,6b-dihydroxytropane, and...
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