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Catalytic asymmetric conjugate addition of terminal alkynes to [small beta]-trifluoromethyl [small alpha],[small beta]-enones

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Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C3CC48508K, Communication
Amparo Sanz-Marco, Andrea Garcia-Ortiz, Gonzalo Blay, Jose R Pedro
The first enantioselective conjugate alkynylation of [small beta]-trifluoromethyl [small alpha],[small beta]-enones using terminal alkynes and a taniaphos-Cu(I) complex as catalyst is described. Ketones bearing a trifluoromethylated propargylic chiral centre in the [small beta]-position were...
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