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First Enzymatic Hydrolysis/Thio-Michael Addition Cascade Route to AChE Inhibitors

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Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC48871C, Communication
Emilia Oueis, Florian Nachon, Cyrille Sabot, Pierre-Yves Renard
The irreversible Michael addition of thiols to acrylamides is reported as a new tool for the kinetic target guided synthesis. In an unprecedented enzymatic hydrolysis/thio-Michael addition procedure, potent and selective...
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