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A copper-mediated tandem reaction through isocyanide insertion into N-H bonds: efficient access to unsymmetrical tetrasubstituted ureas

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Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3CC47590E, Communication
Xiaomei Huang, Shuguang Xu, Qitao Tan, Mingchun Gao, Minjie Li, Bin Xu
A copper-mediated multi-component reaction was developed through isocyanide insertion into N-H bonds of less active secondary arylamines. This approach leads to an efficient synthesis of unsymmetrical tetrasubstituted ureas in one pot.
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