Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase [small alpha]- but not [small beta]- inhibit the phosphatidylinostiol signaling cascade and cancer cell proliferation

Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC48391F, Communication

M J Waring, David M Andrews, Paul F. Faulder, Vikki Flemington, Jennifer McKelvie, Sarita Maman, Piotr Raubo, Graeme Robb, Karen Roberts, Rachel Rowlinson, James M. Smith, Martin Swarbrick, Iries Treinies, Jonathan Winter, Robert Wood, Marian Preston
Two series of inhibitors of type III phosphatidylinositol-4-kinase were identified by high throughput screening and optimised to derive probe compounds that independently and selectively inhibit the [small alpha]- and the [small beta]-...
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