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Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

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Chem. Commun., 2013, 49,11503-11505
DOI: 10.1039/C3CC46617E, Communication
Natsuhisa Oka, Yasuhiro Morita, Yuta Itakura, Kaori Ando
Inosine derivatives bearing a phosphodiester group at the O6-position of the nucleobase were synthesized via phosphitylation of the carbonyl oxygen using phosphoramidites activated by a non-nucleophilic acidic activator.
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