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Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes

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Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC44250K, Communication
Anil Kumar Kusunuru, Madhubabu Tatina, Syed Khalid Yousuf, Debaraj Mukherjee
A highly stereoselective C-glycosylation reaction between glycal and unactivated alkynes using catalytic amount of Copper triflate has been developed. A wide variety of glycals and aryl acetylenes participate in the reaction smoothly. TfOH generated during the reduction of Cu(OTf)2 by ascorbic acid may be the active catalyst for the glycosylation.
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