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Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells

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Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC45752D, Communication
Peng An, Zhipeng Yu, Qing Lin
A terthiophene-tetrazole was identified that undergoes a 405 nm laser-triggered photoclick reaction with a fumarate dipolarophile with the second-order rate constant exceeding 103 M-1 s-1. The real-time spatiotemporally controlled imaging of microtubules in live mammalian cells using this new class of laser-activatable reagent was demonstrated.
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