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Efficient Asymmetric Synthesis of Lamivudine via Enzymatic Dynamic Kinetic Resolution

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Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC45551C, Communication
Lei Hu, Fredrik Schaufelberger, Yan Zhang, Olof Ramstrom
The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using...
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