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Templated alkylation of hexahistidine with Baylis-Hillman esters

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Chem. Commun., 2013, 49,9042-9044
DOI: 10.1039/C3CC43271H, Communication
Xing Xin Liu, Artem Melman
The hexahistidine tag of recombinant proteins was alkylated by Baylis-Hillman esters in the presence of Cu2+ or Zn2+.
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