A novel approach for the one-pot preparation of [small alpha]-ketoamides by anodic oxidation

Chem. Commun., 2013, 49,8982-8984
DOI: 10.1039/C3CC43685C, Communication

Zhenlei Zhang, Jihu Su, Zhenggen Zha, Zhiyong Wang
The direct oxidative synthesis of [small alpha]-ketoamides via anodic oxidation was developed by using dioxygen as a reactant under mild conditions. This methodology has a broad substrate scope (aromatic amines, aliphatic amines and ammonium acetate) and opens up an interesting and attractive avenue for the synthesis of [small alpha]-ketoamide derivatives.
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