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exo-Selective Construction of Spiro-[butyrolactone-pyrrolidine] via 1,3-Dipolar Cycloaddition of Azomethine Ylides with alpha-Methylene-gamma-butyrolactone Catalyzed by Cu(I)/DTBM-BIPHEP

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Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC45493B, Communication
Chun-Jiang Wang, Qing-Hua Li, Tang-Lin Liu, Liang Wei, Xiang Zhou, Hai-Yan Tao
An expedient access to optically active spiro-[butyrolactone-pyrrolidine] was successfully developed via an unprecedented Cu(I)-catalyzed exo-selective 1,3-DC of azomethine ylides with alpha-Methylene-gamma-butyrolactone, which exhibited high diastereoselectivity (>98:2), excellent enantioselectivity (96->99% ee)...
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