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Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase

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Chem. Commun., 2013, 49,5535-5537
DOI: 10.1039/C3CC40758F, Communication
Daisuke Hayashi, Nobuo Kato, Tomohisa Kuzuyama, Yasuo Sato, Junko Ohkanda
A simple hydroxamate, derived from hydrolysis of ketoclomazone, was found to inhibit Haemophilus influenzae 1-deoxy-D-xylulose 5-phosphate synthase at the low [small mu ]M range and suppress bacterial growth.
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