Chem. Commun., 2013, 49,8181-8183
DOI: 10.1039/C3CC44401E, Communication
DOI: 10.1039/C3CC44401E, Communication
Feng Zheng, Derek A. Pratt
We demonstrate that the garlic-derived chemopreventive agent allicin and the related anamu-derived petivericin are poor radical-trapping antioxidants in lipid bilayers, but that the in situ reaction of a lipophilic analog and a hydrophilic thiol yields an extremely potent radical-trapping antioxidant that can be recycled in the presence of excess thiol.
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We demonstrate that the garlic-derived chemopreventive agent allicin and the related anamu-derived petivericin are poor radical-trapping antioxidants in lipid bilayers, but that the in situ reaction of a lipophilic analog and a hydrophilic thiol yields an extremely potent radical-trapping antioxidant that can be recycled in the presence of excess thiol.
The content of this RSS Feed (c) The Royal Society of Chemistry