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Asymmetric Synthesis of 3-Spirocyclopropyl-2-oxindoles via Intramolecular Trapping of Chiral Aza-ortho-xylylene

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Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC45369C, Communication
Xiaowei Dou, Weijun Yao, Bo Zhou, Yixin Lu
Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.
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