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Heterogeneous and homogeneous chiral Cu(II) catalysis in water: enantioselective boron conjugate additions to dienones and dienoesters

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Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC44324H, Communication
Taku Kitanosono, Pengyu Xu, Shu Kobayashi
It was proved that a judicious choice of counteranion played a prominent role in Cu(II) catalysis for enantioselective boron conjugate additions in water; the use of Cu(OH)2 renders heterogeneous catalysis, whereas Cu(OAc)2 renders homogeneous catalysis; cyclic dienones underwent a remarkable switch of regioselectivity between 1,4- and 1,6-modes of the additions through these catalyses.
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