Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC44667K, Communication
DOI: 10.1039/C3CC44667K, Communication
Nojoon Myung, Stephen Connelly, Boyoung Kim, Sung Jean Park, Ian A Wilson, Jeff Kelly, Sungwook Choi
We describe a coumarin derivative that is non-fluorescent in aqueous buffers and that very selectively binds to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.
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We describe a coumarin derivative that is non-fluorescent in aqueous buffers and that very selectively binds to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.
The content of this RSS Feed (c) The Royal Society of Chemistry