Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC45454A, Communication
DOI: 10.1039/C3CC45454A, Communication
Maria Chiara Monti, Chiara Cassiano, Roberta Esposito, Alessandra Tosco, Angela Zampella, Maria Valeria D'Auria, R Riccio, Agostino Casapullo
Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as heteronemin novel target by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the TDP-43-cognate nucleic acids binding and to modulate TDP-43 aggregation state and its cellular localization.
The content of this RSS Feed (c) The Royal Society of Chemistry
Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as heteronemin novel target by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the TDP-43-cognate nucleic acids binding and to modulate TDP-43 aggregation state and its cellular localization.
The content of this RSS Feed (c) The Royal Society of Chemistry