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Electrostatics and Flexibility Drive Membrane Recognition and Early Penetration by Antimicrobial Peptide Dendrimer bH1

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Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC44912B, Communication
Harish Kumar Ravi, Michaela Stach, Thereza A. Soares, Tamis Darbre, Jean-Louis Reymond, Michele Cascella
Molecular dynamics simulation of polycationic antimicrobial peptide dendrimer bH1 (Leu)8(DapLeu)4(DapPhe)2DapLys-NH2 binding to membranes suggest that electrostatic interactions with the polyanionic lipopolysaccharide (LPS) and conformational flexibility of the 2,3-diaminopropanoic acid (Dap)...
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