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Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent

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Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC44962A, Communication
Thorfinnur Gunnlaugsson, Swagata Banerjee, Jonathan A Kitchen, Sandra Bright, John E O'Brien, D. Clive Williams, J M Kelly
The bi-functional complex [PtII(terpy)(py-naphth)](NO3)2 (1), incorporating both 2,2':6',2''-terpyridine and 4-N,N'-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.
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