Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC44737E, Communication
DOI: 10.1039/C3CC44737E, Communication
Pierre Murat, Michael V Gormally, Debbie Sanders, Marco Di Antonio, Shankar Balasubramanian
The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
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The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry