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Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

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Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC44434A, Communication
Yoshihiro Miyake, Shin-ichi Ota, Masashi Shibata, Kazunari Nakajima, Yoshiaki Nishibayashi
Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a high selectivity.
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